[摘要] 多文娱乐(luodw.com)科研工作 在研项目(2017年)(1)“高活性的、ROCK2/1亚型选择性的ROCK2抑制剂的设计与合成研究”,2016年国家自然基金,负责人。(2)‘“可再生燃料电池用一体化双功
多文娱乐(luodw.com)科研工作 在研项目(2017年)(1)“高活性的、ROCK2/1亚型选择性的ROCK2抑制剂的设计与合成研究”,2016年国家自然基金,负责人。(2)‘“可再生燃料电池用一体化双功能催化剂的开发”,上海市科促会2016年联盟计划,负责人。(3)“3,3’-联二噻吩衍生物的合成及其应用研究”,2016年上海市分子催化和功能材料重点实验室研究基金,负责人。(4)“含氟Limk1抑制剂的设计、合成及应用研究”,2017年中国科学院有机氟化学重点实验室开放基金,负责人。(5)“基于“应用型”本科人才培养的《高分子材料基础》课程教学改革的探索与实践”,2015年上海应用技术学院校级教改项目,负责人。(6)“关于提高学术学位研究生创新能力的探索与实践”,2016年上海应用技术学院研究生教改项目,负责人。(7)“阿司匹林的制备及其质量控制”,2016年校企合作实验项目,负责人。(8)“大学生科创与制药工程专业应用型人才培养模式研究”,2016年上海应用技术大学高教课题,负责人。代表性论文(1)FengkaiCheng,YanYin*,GuozhenZhang,*,YuanWang,WeiDeng,FanhongWu“Optoelectronicandthermalpropertiesofhighlyfluorescenceemissive2,2’-distyryl-[3,3']-bithiophenes“Dyesandpigments2017,140,222-228(SCI,IF=4.0).(2)RuihongTao,YanYin*,YongbinDuan,YuxingSun,YueSun,FengkaiCheng,JinpengPan,ChenLu,YuanWangTetrahedron2017,10.1016/j.tet.2017.02.030(SCI,IF=2.6)(3)ZhaoZhao,JiaxinCui,YanYin,*HengZhang,YechengLiu,RuiZeng,ChaoFang,ZhenpengKai,ZhonghuaWang,*FanhongWua*“Synthesisandbiologicalevaluationofgem-difluoromethylenatedstatinderivativesashighlypotentHMG-CoAreductaseinhibitorsChin.J.Chem.2016,34,801-808(SCI,IF=1.9).(4)GuofengSun,FengkaiCheng,RuihengTao,YuxingSun,JinpengPang,Zhonghua,YaohuaZhu,ZhonghuaWang,FanhongWu,YanYin*“Superacid-catalyzedTandemMeyer-SchusterRearrangement/IntramolecularHydroaminationofo-AniliopropargyAlcoholstoSynthesize2,3-Dihydro-4(1H)-quinolones”Synth.Commun.2016,46,1249-1256(SCI,IF=1.0).(5)YanYin,KeZheng,NibalEid,ShannonHoward,Ji-HakJeong,FeiYi,JiaGuo,ChuiMinPark,MathieuBibian,WeilinWu,PamelaHernandez,HaJeungPark,YuntaoWu,Jun-LiLuo,PhilipV.Lograsso,YangboFeng“Bis-arylderivativesaspotentandselectiveLimkinaseinhinitors”J.Med.Chem.2015,58,1846-1861.(SCI,IF=5.6)(6)MeiDing,YanYin*,FanhongWu,JiaxingCui,HongZhou,GuofengSun,YuJiang,YangboFeng*“Discoveryofpotentandselectiveurea-basedROCKinhibitors:Exploringtheinhibitor’spotencyandROCK2/PKAselectivityby3D-QSAR,moleculardockingandmoleculardynamicssimulations”Bioorg.Med.Chem.2015,23,2505-2517(SCI,IF=2.9).(7)JiaxinCui,MeiDing,YanYin*,WeiDeng,ZhonghuaWang,YuJiang,HongZhou,GuofengSun,YangboFeng“Discoveryofbis-aryureaderivativesaspotentandselectiveLimkinhibitors:ExploringLimk1activityandLimk1/ROCK2selectivitythroughcomputationalstudies”Bioorg.Med.Chem.2015,23,7464-7477(SCI,IF=2.9)(8)YanYin*,HongZhou,XichenLiu,HaiyingChen,FanhongWu,HengZhang,RuihengTao,FengkaiCheng,YangboFeng“AMetal-FreeandRecyclableSynthesisofBenzothiazolesusingThioureaasaSulfurSurrogate”TetrahedronLett,2015,56,1709-1712.(SCI,IF=2.4)(9)YanYin*,HongZhou,GuofengSun,XichenLiu“m-CPBAMediatedIntramolecularAminohydroxylationofN-SulfonylAminoalkenestoSynthesizeβ-hydroxylCyclicAmines”JournalofHeterocyclicChemistry2015,1337-1345(SCI,IF=0.8)(10)YanYin*,Guo-FengSun,HengZhang,HongZhou,Fan-Hong,Wu“EnatioselectiveChalcogeno-Baylis-HillmanReactionofBenzaldehydeswithMVKandAcrylatesCatalyzedbyChiralThiepin-TiCl4Complex”Chin.J.Chem.2014,32,365-369.(SCI,IF=1.9)(11)YanYinLiLinClaudiaRuizSusanKhanMichaelDCameronWayneGrantJenniferPocasNibalEidHajeungParkThomasSchroeterPhilipV.LoGrassoYangboFeng“SynthesisandBiologicalEvaluationofUreaDerivativesasHighlyPotentandSelectiveRhoKinaseInhibitors”J.Med.Chem.2013,56,3568-3581。(SCI,IF=5.6)(12)YanYin,MichaelD.Cameron,LiLin,SusanKhan,ThomasSchrter,WayneGrant,JenniferPocas,YenTingChen,StephanSchrer,AlokPachori,PhilipLoGrasso*,YangboFeng*“DiscoveryofHighlyPotentandSelectiveUrea-basedROCKinhibitorsandtheireffectsontheintraocularpressureinrats”ACSMed.Chem.Lett.2010,1,175-179.(SCI,IF=3.2)(13)YanYin,LiLin,ClaudiaRuiz,MichaelD.Cameron,JenniferPocas,WayneGrant,ThomasSchrter,WeiminChen,DerekDuckett,StephanSchrer,PhilipLoGrasso,YangboFeng*“BenzothiazolesasRho-associatedkinase(ROCK-II)inhibitors”Bioorg.Med.Chem.Lett.2009,19,6686-6690.(SCI,IF=2.4)(14)YanYin,ZhuoChai,Wen-YingMa,GangZhao*“Synthesisofindolesviadiethylzinc-mediatedintramolecularhydroaminationreactionofalkynylsulfonamides”Synthesis2008,24,4036-4040.(15)YanYin,WenyingMa,ZhuoChai,GangZhao*“Et2Zn-CatalyzedIntramolecularHydroaminationofAminoalkynesandTandemCyclization/NucleophilicAdditionthroughtheIndoleZincSaltIntermediate”J.Org.Chem.2007,72,5731-5736.(16)YanYin,GangZhao*“HeptadecafluorooctanesulfonicAcid(C8F17SO3H)CatalyzedIntramolecularHydroaminationofOlefinicSulfonamidesinFluorousBiphaseSystem(FBS)”J.FluorineChem.2007,128,40-45.(17)YanYin,GangZhao*’”PerfluoroussuperacidC8F17SO3H-catalyzedintramolecularhydroaminationreactionofN-protected2-alkynylanilines:anovelsyntheticmethodforindoles”ChimicaOggi-ChemistryToday2007,25,42-45.(18)YanYin,GangZhao*“SynthesisofIndolinesandQuinolineviaCyclizationo(《与妻书》最出名的一句话是什么?《与妻书》最出名的一句话是:吾今与汝无言矣!吾居九泉之下,遥闻汝哭声,当哭相和也。吾平日不信有鬼,今则又望其真有。今人又言心电感应有道,吾亦望其言是实,则吾之死,吾灵尚依依旁汝也,汝不必以无侣悲!)fN-Arylsulfonyl-2-allylanilinesCatalyzedbyBrnstedAcid”Heterocycles2006,68,23-31.
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